Monday, September 19, 2016

Phenylephrine/Carbetapentane/Guaifenesin


Pronunciation: FEN-il-EF-rin/ kar-bay-ta-PEN-tane/gwye-FEN-e-sin
Generic Name: Phenylephrine/Carbetapentane/Guaifenesin
Brand Name: Aquatab C


Phenylephrine/Carbetapentane/Guaifenesin is used for:

Relieving congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.


Phenylephrine/Carbetapentane/Guaifenesin is a decongestant, cough suppressant, and expectorant combination. It works by constricting blood vessels, reducing swelling in the nasal passages, and loosening mucus and lung secretions in the chest, making coughs more productive. The cough suppressant works in the brain to help decrease the cough reflex.


Do NOT use Phenylephrine/Carbetapentane/Guaifenesin if:


  • you are allergic to any ingredient in Phenylephrine/Carbetapentane/Guaifenesin

  • you have uncontrolled high blood pressure, rapid heartbeat, or other severe heart problems (eg, heart blood vessel disease)

  • you take droxidopa or have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.



Before using Phenylephrine/Carbetapentane/Guaifenesin:


Some medical conditions may interact with Phenylephrine/Carbetapentane/Guaifenesin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a history of glaucoma or increased pressure in the eye, enlarged prostate gland or other prostate problems, heart problems, diabetes, high blood pressure, blood vessel problems, adrenal gland problems (eg, pheochromocytoma), mental or mood problems (eg, depression), trouble sleeping, an overactive thyroid, seizures, or stroke

  • if you have a chronic cough, chronic obstructive pulmonary disease (COPD), or other lung problems (eg, asthma, chronic bronchitis, emphysema), or if your cough produces large amounts of mucus

  • if you are in poor health or very overweight

Some MEDICINES MAY INTERACT with Phenylephrine/Carbetapentane/Guaifenesin. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased

  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone , indomethacin, MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Phenylephrine/Carbetapentane/Guaifenesin's side effects

  • Alpha-blockers (eg, prazosin) and bromocriptine because the risk of their side effects may be increased by Phenylephrine/Carbetapentane/Guaifenesin

  • Guanadrel, guanethidine, mecamylamine, medicines for high blood pressure, methyldopa, or reserpine because their effectiveness may be decreased by Phenylephrine/Carbetapentane/Guaifenesin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Phenylephrine/Carbetapentane/Guaifenesin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Phenylephrine/Carbetapentane/Guaifenesin:


Use Phenylephrine/Carbetapentane/Guaifenesin as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Take Phenylephrine/Carbetapentane/Guaifenesin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

  • Swallow Phenylephrine/Carbetapentane/Guaifenesin whole. Do not break, crush, or chew before swallowing. Some brands of Phenylephrine/Carbetapentane/Guaifenesin may be broken in half before taking. If you have difficulty swallowing the whole tablet, ask your pharmacist if your brand of medicine may be broken in half.

  • Take Phenylephrine/Carbetapentane/Guaifenesin with a full glass of water (8 oz/240 mL).

  • Drink plenty of water while taking Phenylephrine/Carbetapentane/Guaifenesin.

  • If you miss a dose of Phenylephrine/Carbetapentane/Guaifenesin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Phenylephrine/Carbetapentane/Guaifenesin.



Important safety information:


  • Phenylephrine/Carbetapentane/Guaifenesin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Phenylephrine/Carbetapentane/Guaifenesin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

  • Do not use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Phenylephrine/Carbetapentane/Guaifenesin; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

  • Do not take appetite suppressants while you are taking Phenylephrine/Carbetapentane/Guaifenesin without checking with your doctor.

  • Phenylephrine/Carbetapentane/Guaifenesin has phenylephrine, carbetapentane, and guaifenesin in it. Before you start any new medicine, check the label to see if it has phenylephrine, carbetapentane, or guaifenesin in it too. If it does or if you are not sure, check with your doctor or pharmacist.

  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

  • If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor or pharmacist.

  • If cough persists for more than 1 week or is accompanied by a fever, headache, rash, or sore throat, contact your health care provider. A persistent cough could be a sign of a serious condition.

  • Do not use Phenylephrine/Carbetapentane/Guaifenesin for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.

  • Phenylephrine/Carbetapentane/Guaifenesin may interfere with certain lab tests. Be sure that your doctor and lab personnel know you are taking Phenylephrine/Carbetapentane/Guaifenesin.

  • Tell your doctor or dentist that you take Phenylephrine/Carbetapentane/Guaifenesin before you receive any medical or dental care, emergency care, or surgery.

  • Use Phenylephrine/Carbetapentane/Guaifenesin with caution in the ELDERLY; they may be more sensitive to its effects.

  • Caution is advised when using Phenylephrine/Carbetapentane/Guaifenesin in CHILDREN; they may be more sensitive to its effects.

  • Phenylephrine/Carbetapentane/Guaifenesin should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: It is not known if Phenylephrine/Carbetapentane/Guaifenesin can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Phenylephrine/Carbetapentane/Guaifenesin while you are pregnant. It is not known if Phenylephrine/Carbetapentane/Guaifenesin is found in breast milk. Do not breast-feed while taking Phenylephrine/Carbetapentane/Guaifenesin.


Possible side effects of Phenylephrine/Carbetapentane/Guaifenesin:


All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Diarrhea; dizziness; drowsiness; excitability; headache; irritability; nausea; stomach upset; trouble sleeping.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast, slow, or irregular heartbeat; fever; hallucinations; mental or mood changes (eg, anxiety, nervousness); paleness; seizures; severe or persistent dizziness, headache, or lightheadedness; tremor.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Phenylephrine/Carbetapentane/Guaifenesin side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include bizarre behavior; blurred vision; confusion; difficulty urinating; fast or shallow breathing; hallucinations; paleness; restlessness; seizures; severe dizziness, headache, or lightheadedness; severe drowsiness; tremor; unusually fast, slow, or irregular heartbeat; vomiting.


Proper storage of Phenylephrine/Carbetapentane/Guaifenesin:

Store Phenylephrine/Carbetapentane/Guaifenesin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Phenylephrine/Carbetapentane/Guaifenesin out of the reach of children and away from pets.


General information:


  • If you have any questions about Phenylephrine/Carbetapentane/Guaifenesin, please talk with your doctor, pharmacist, or other health care provider.

  • Phenylephrine/Carbetapentane/Guaifenesin is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Phenylephrine/Carbetapentane/Guaifenesin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Phenylephrine/Carbetapentane/Guaifenesin resources


  • Phenylephrine/Carbetapentane/Guaifenesin Side Effects (in more detail)
  • Phenylephrine/Carbetapentane/Guaifenesin Use in Pregnancy & Breastfeeding
  • Phenylephrine/Carbetapentane/Guaifenesin Drug Interactions
  • Phenylephrine/Carbetapentane/Guaifenesin Support Group
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